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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1987-4-17
|
| pubmed:abstractText |
The inhibitory effect of niridazole on hydrogen production by metronidazole-resistant (CDC-85) and susceptible (C1-NIH) Trichomonas vaginalis strains was investigated. The results show that niridazole is more effective than metronidazole in inhibiting hydrogen production by the resistant isolate. In CDC-85 aerobic inhibition requires a 4-fold increase in metronidazole concentration compared with that required anaerobically, but the corresponding factor for niridazole is only 1.5-fold. Reduction of the drug by a hydrogenosome-enriched preparation gave rise to a multiline electron spin resonance detectable signal, which is due to a nitrogen-centred radical.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0031-1820
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
94 ( Pt 1)
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
93-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3029651-Animals,
pubmed-meshheading:3029651-Carbon Dioxide,
pubmed-meshheading:3029651-Drug Resistance,
pubmed-meshheading:3029651-Electron Spin Resonance Spectroscopy,
pubmed-meshheading:3029651-Hydrogen,
pubmed-meshheading:3029651-Mass Spectrometry,
pubmed-meshheading:3029651-Metronidazole,
pubmed-meshheading:3029651-Niridazole,
pubmed-meshheading:3029651-Oxidation-Reduction,
pubmed-meshheading:3029651-Trichomonas vaginalis
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Reduction of niridazole by metronidazole resistant and susceptible strains of Trichomonas vaginalis.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|