Linked Life Data

3028550

Source:http://linkedlifedata.com/resource/pubmed/id/3028550

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-4-2
pubmed:abstractText
The effects of N-(cyclopropylmethyl)-19-isopentylnororvinol hydrochloride (M320) on urine excretion by rats were investigated. Further studies, using rabbit isolated vas deferens, investigated its interactions with kappa-opiate receptors. The output of urine for a 2 h period after M320, administered subcutaneously to normally hydrated Long Evans rats, showed a bell-shaped dose-response relationship, the maximum effect occurring after 10 micrograms kg-1. Urinary retention contributed to but did not fully account for the weaker diuresis after high doses. Attenuation of the ascending portion of the dose-response curve to M320 occurred after 1 and 10 mg kg-1 but not 0.1 mg kg-1 of naltrexone intraperitoneally. M320 in low doses (3-10 micrograms kg-1) caused a small but significant increase in sodium excretion. M320 (30 micrograms kg-1) reduced both sodium and potassium excretion. M320 (10 micrograms kg-1 s.c.) did not increase the volume of urine voided in 2 h by Brattleboro rats showing diabetes insipidus, even when urine excretion was reduced to normal by 1 week of vasopressin replacement. The volume of urine voided in 4 h by Brattleboro rats was progressively reduced to zero by M320 (10-100 micrograms kg-1 s.c.). Urinary retention contributed to but did not account for this reduction. Plasma levels of immunoreactive arginine vasopressin (ir-AVP) were reduced in both normal and dehydrated Long Evans rats after doses greater than 1 microgram kg-1 M320 s.c. In vitro, M320 caused persistent inhibition of twitches of the electrically stimulated rabbit vas deferens (IC50 1.7 nM). 8 These data suggest that M320 has potent opioid agonist activity at K-receptors and at higher concentrations stimulates mu- receptors. In the rat, its activity on K-receptors is associated with diuresis and suppression of plasma vasopressin levels. The antidiuresis seen after high doses may be due to its activity on mu-receptors, possibly at a central site.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-1223660, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-14334338, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-4958020, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-574456, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-6094203, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-6094211, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-6121047, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-6137557, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-6253759, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-6258694, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-6273188, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-6294284, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-6356937, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-6714302, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-6722535, http://linkedlifedata.com/resource/pubmed/commentcorrection/3028550-7083068
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
759-67
pubmed:dateRevised
2010-5-12
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
The effects of N-(cyclopropylmethyl)-19-isopentylnororvinol (M320), a potent agonist at kappa- and mu-opiate receptors, on urine excretion of rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't