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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1987-2-25
|
| pubmed:abstractText |
Liver cell dysplasia (LCD) is a premalignant cytologic change of hepatocytes that has been statistically linked to cirrhosis, hepatocellular carcinoma (HCC), and chronic liver disease related to hepatitis B virus. The relationship of LCD to non-A, non-B (NANB) hepatitis is currently unknown. We studied liver biopsy and surgical resection specimens from 36 patients with NANB hepatitis, and identified LCD in 17 (42.5%) of 40 specimens, most often associated with cirrhosis. Dysplasia was present in individual hepatocytes, in clusters, and in a distinctive "spreading" pattern of hepatocytes about central veins. Three patients had HCC with a predominant giant cell pattern, as well as LCD. These findings suggest that LCD and HCC should be included among the potential pathologic sequelae of NANB hepatitis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0003-9985
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
111
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
170-3
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3028314-Carcinoma, Hepatocellular,
pubmed-meshheading:3028314-Hepatitis, Viral, Human,
pubmed-meshheading:3028314-Hepatitis C,
pubmed-meshheading:3028314-Humans,
pubmed-meshheading:3028314-Liver,
pubmed-meshheading:3028314-Liver Cirrhosis,
pubmed-meshheading:3028314-Liver Neoplasms,
pubmed-meshheading:3028314-Precancerous Conditions
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Liver cell dysplasia and hepatocellular carcinoma in non-A, non-B hepatitis.
|
| pubmed:publicationType |
Journal Article
|