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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1987-3-4
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|
pubmed:abstractText |
We have initiated the molecular definition of the antigens recognized by Gross MuLV-specific cytolytic T lymphocytes on the surface of Gross MuLV-induced tumor cells. A panel of target cells was obtained by the double transfection and expression of a retrovirus gene and a foreign H-2 gene in recipient mouse fibroblasts. Our results show that class I H-2 transplantation antigens have a directive influence in determining the antigenicity of proteins encoded by the gag and env MuLV genes. Genes not linked to H-2 influence the intensity and the specificity of the cytolytic T lymphocyte response to Gross MuLV-induced tumors. Finally, MuLV-induced antigens expressed by transfected fibroblasts induce tumor immunity and lead to accelerated tumor rejection in vivo.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jan
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|
pubmed:issn |
0092-8674
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
30
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|
pubmed:volume |
48
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
231-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3026637-AKR murine leukemia virus,
pubmed-meshheading:3026637-Animals,
pubmed-meshheading:3026637-Antigens, Viral,
pubmed-meshheading:3026637-Gene Products, gag,
pubmed-meshheading:3026637-Genes, Viral,
pubmed-meshheading:3026637-H-2 Antigens,
pubmed-meshheading:3026637-Leukemia, Experimental,
pubmed-meshheading:3026637-Leukemia Virus, Murine,
pubmed-meshheading:3026637-Mice,
pubmed-meshheading:3026637-Mice, Inbred BALB C,
pubmed-meshheading:3026637-Mice, Inbred C57BL,
pubmed-meshheading:3026637-Mice, Inbred Strains,
pubmed-meshheading:3026637-Retroviridae Proteins,
pubmed-meshheading:3026637-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:3026637-Transfection,
pubmed-meshheading:3026637-Viral Envelope Proteins
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pubmed:year |
1987
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|
pubmed:articleTitle |
Retrovirus antigens recognized by cytolytic T lymphocytes activate tumor rejection in vivo.
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pubmed:publicationType |
Journal Article
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