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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1987-3-20
|
| pubmed:abstractText |
The experiments were carried out to elucidate the effect of carboxycathepsin (CC) activity inhibition by a specific inhibitor--captopril--on plasma enzyme concentration in normotensive rats and rats with renovascular hypertension. A single oral administration of captopril (10 mg/kg body weight) produced an increase in CC concentration in both hypertensive and sodium-depleted normotensive rats with a parallel decrease in arterial pressure, but had no effect on sodium-repleted normotensive rats. It is suggested that the increase in plasma CC concentration is a compensatory response to the inhibition of CC activity by captopril; it is also possible that the increase observed reflects the state of renin-angiotensin system.
|
| pubmed:language |
rus
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0365-9615
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
103
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
48-50
|
| pubmed:dateRevised |
2008-10-8
|
| pubmed:meshHeading |
pubmed-meshheading:3026518-Animals,
pubmed-meshheading:3026518-Blood Pressure,
pubmed-meshheading:3026518-Captopril,
pubmed-meshheading:3026518-Diet, Sodium-Restricted,
pubmed-meshheading:3026518-Enzyme Induction,
pubmed-meshheading:3026518-Female,
pubmed-meshheading:3026518-Hypertension, Renovascular,
pubmed-meshheading:3026518-Peptidyl-Dipeptidase A,
pubmed-meshheading:3026518-Rats,
pubmed-meshheading:3026518-Time Factors
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
[Induction of blood plasma carboxycathepsin (angiotensin I-converting enzyme) in normo- and hypertensive rats in response to a single administration of captopril].
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
|