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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1987-2-2
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pubmed:abstractText |
A combination of DIP-thrombin and either PMA (50 ng/ml) or dioctanoyl glycerol stimulates DNA synthesis in serum free cultures of NIL hamster cells similar to that previously reported for the combinatory effect of DIP-thrombin and gamma-thrombin. Thus, PMA or dioctanoyl glycerol appears to generate signals normally stimulated by gamma-thrombin interaction with cells. This stimulation was not observed when cells were treated with DIP-thrombin and 4-beta-phorbol or 4-alpha-phorbol 12,13-didecanoate. Therefore, it appears that this effect is mediated through activation of protein kinase C and that this activation plays an important role in thrombin mitogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-291X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
141
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
650-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3026387-Animals,
pubmed-meshheading:3026387-Cell Cycle,
pubmed-meshheading:3026387-Cell Line,
pubmed-meshheading:3026387-Cricetinae,
pubmed-meshheading:3026387-Diglycerides,
pubmed-meshheading:3026387-Drug Synergism,
pubmed-meshheading:3026387-Phorbol Esters,
pubmed-meshheading:3026387-Protein Kinase C,
pubmed-meshheading:3026387-Receptors, Cell Surface,
pubmed-meshheading:3026387-Receptors, Thrombin,
pubmed-meshheading:3026387-Structure-Activity Relationship,
pubmed-meshheading:3026387-Tetradecanoylphorbol Acetate,
pubmed-meshheading:3026387-Thrombin
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pubmed:year |
1986
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pubmed:articleTitle |
Thrombin receptor occupancy initiates cell proliferation in the presence of phorbol myristic acetate.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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