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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1987-2-17
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pubmed:databankReference |
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pubmed:abstractText |
We deduced the complete amino acid sequence of the rat brain Na,K-ATPase beta-subunit from cDNA. The rat brain beta-subunit exhibits a high degree of primary sequence and secondary structural homology with the human and Torpedo beta-subunit polypeptides. Analysis of rat tissue RNA reveals that the beta-subunit gene encodes four separate mRNA species which are expressed in a tissue-specific fashion. In ouabain-resistant HeLa C+ cells, beta-subunit DNA sequences are amplified (approximately 20-fold) and beta-subunit mRNAs are overproduced relative to levels in parental HeLa cells. These results suggest that the beta-subunit plays an important role in Na,K-ATPase structure-function and in the mechanism underlying cellular resistance to the cardiac glycosides.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-2410405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-2994074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-3005037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-3008098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-3017414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-3023874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-3023935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-354496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-3991809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-4200179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-6088560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-6219389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-6254030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-6265783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-6289678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-6289898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-6329026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-6575390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-6694911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-7108955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-822353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3025616-881736
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3884-90
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3025616-Amino Acid Sequence,
pubmed-meshheading:3025616-Animals,
pubmed-meshheading:3025616-Base Sequence,
pubmed-meshheading:3025616-Brain,
pubmed-meshheading:3025616-Cloning, Molecular,
pubmed-meshheading:3025616-DNA,
pubmed-meshheading:3025616-Drug Resistance,
pubmed-meshheading:3025616-Gene Amplification,
pubmed-meshheading:3025616-Genes,
pubmed-meshheading:3025616-HeLa Cells,
pubmed-meshheading:3025616-Humans,
pubmed-meshheading:3025616-Macromolecular Substances,
pubmed-meshheading:3025616-Ouabain,
pubmed-meshheading:3025616-Rats,
pubmed-meshheading:3025616-Sodium-Potassium-Exchanging ATPase,
pubmed-meshheading:3025616-Species Specificity,
pubmed-meshheading:3025616-Torpedo
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pubmed:year |
1986
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pubmed:articleTitle |
Rat-brain Na,K-ATPase beta-chain gene: primary structure, tissue-specific expression, and amplification in ouabain-resistant HeLa C+ cells.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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