| pubmed-article:302450 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:302450 | lifeskim:mentions | umls-concept:C0242275 | lld:lifeskim |
| pubmed-article:302450 | lifeskim:mentions | umls-concept:C0034800 | lld:lifeskim |
| pubmed-article:302450 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:302450 | lifeskim:mentions | umls-concept:C2347885 | lld:lifeskim |
| pubmed-article:302450 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:302450 | pubmed:dateCreated | 1977-10-14 | lld:pubmed |
| pubmed-article:302450 | pubmed:abstractText | A photoreactive derivative of epidermal growth factor (EGF) has been used to identify and specifically label a membrane receptor for EGF on mouse 3T3 cells. Photoactivable EGF, labeled with 125I, was incubated with 3T3 cells and then photolyzed in situ to generate a nitrene capable of reacting with a wide variety of chemical bonds. Analysis of the system by sodium dodecyl sulfate/polyacrylamide gel electrophoresis revealed, besides the band of EGF, only one other major radioactive band, at a position indicating an apparent molecular weight of 190,000. This band was absent when a nonresponsive and nonbinding variant of 3T3 was used. A direct proportionality between binding activity and crosslinked complex formation was demonstrated using a variety of binding conditions. "Down regulated" cells, in which EGF binding activity was greatly reduced by prolonged incubation with an appropriate concentration of EGF, also had a decrease in covalent complex formation proportional to the decrease in EGF binding activity. | lld:pubmed |
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| pubmed-article:302450 | pubmed:language | eng | lld:pubmed |
| pubmed-article:302450 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:302450 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:302450 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:302450 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:302450 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:302450 | pubmed:author | pubmed-author:HerschmanH... | lld:pubmed |
| pubmed-article:302450 | pubmed:author | pubmed-author:FoxC FCF | lld:pubmed |
| pubmed-article:302450 | pubmed:author | pubmed-author:AharonovAA | lld:pubmed |
| pubmed-article:302450 | pubmed:author | pubmed-author:DayGG | lld:pubmed |
| pubmed-article:302450 | pubmed:author | pubmed-author:PrussR MRM | lld:pubmed |
| pubmed-article:302450 | pubmed:author | pubmed-author:MiyakawaTT | lld:pubmed |
| pubmed-article:302450 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:302450 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:302450 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:302450 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:302450 | pubmed:pagination | 2790-4 | lld:pubmed |
| pubmed-article:302450 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:302450 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:302450 | pubmed:articleTitle | Specific radiolabeling of a cell surface receptor for epidermal growth factor. | lld:pubmed |
| pubmed-article:302450 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:302450 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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