| pubmed-article:3023905 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3023905 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:3023905 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:3023905 | lifeskim:mentions | umls-concept:C1707511 | lld:lifeskim |
| pubmed-article:3023905 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3023905 | pubmed:dateCreated | 1987-1-20 | lld:pubmed |
| pubmed-article:3023905 | pubmed:abstractText | Both avian myeloblastosis virus (by the action of v-myb) and avian myelocytomatosis virus MC29 (by the action of v-myc) transform cells of the myelomonocytic lineage. Whereas avian myeloblastosis virus elicits a relatively immature phenotype, cells transformed by MC29 resemble mature macrophages. When cells previously transformed by v-myb were superinfected with MC29, their phenotype was rapidly altered to that of a more mature cell. These superinfected cells expressed both v-myb (at a level similar to that found before superinfection) and v-myc. It therefore appears that the expression of v-myc can elicit certain properties of a more differentiated phenotype. In addition, unlike cells transformed by v-myb alone, the cells expressing both v-myb and v-myc could not be induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate to differentiate to fully mature macrophages. Cells with a morphology similar to that of the superinfected cells were elicited by simultaneously infecting yolk sac macrophages with avian myeloblastosis virus and MC29. Such cells expressed both v-myb and v-myc. These results indicate that expression of v-myb and v-myc in infected cells coordinately regulates myelomonocytic phenotype and that the two viral oncogenes vary in their ability to interfere with tumor promoter-induced differentiation. Our findings also sustain previous suggestions that the oncogenes v-myb and v-myc may not transform target cells by simply blocking differentiation. | lld:pubmed |
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| pubmed-article:3023905 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3023905 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3023905 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3023905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3023905 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3023905 | pubmed:month | May | lld:pubmed |
| pubmed-article:3023905 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:3023905 | pubmed:author | pubmed-author:BishopJ MJM | lld:pubmed |
| pubmed-article:3023905 | pubmed:author | pubmed-author:SnyderMM | lld:pubmed |
| pubmed-article:3023905 | pubmed:author | pubmed-author:MoscoviciCC | lld:pubmed |
| pubmed-article:3023905 | pubmed:author | pubmed-author:SymondsGG | lld:pubmed |
| pubmed-article:3023905 | pubmed:author | pubmed-author:KlempnauerK... | lld:pubmed |
| pubmed-article:3023905 | pubmed:author | pubmed-author:MoscoviciGG | lld:pubmed |
| pubmed-article:3023905 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3023905 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:3023905 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3023905 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3023905 | pubmed:pagination | 1796-802 | lld:pubmed |
| pubmed-article:3023905 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:3023905 | pubmed:meshHeading | pubmed-meshheading:3023905-... | lld:pubmed |
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| pubmed-article:3023905 | pubmed:meshHeading | pubmed-meshheading:3023905-... | lld:pubmed |
| pubmed-article:3023905 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3023905 | pubmed:articleTitle | Coordinate regulation of myelomonocytic phenotype by v-myb and v-myc. | lld:pubmed |
| pubmed-article:3023905 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3023905 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3023905 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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