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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1987-1-20
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pubmed:abstractText |
Both avian myeloblastosis virus (by the action of v-myb) and avian myelocytomatosis virus MC29 (by the action of v-myc) transform cells of the myelomonocytic lineage. Whereas avian myeloblastosis virus elicits a relatively immature phenotype, cells transformed by MC29 resemble mature macrophages. When cells previously transformed by v-myb were superinfected with MC29, their phenotype was rapidly altered to that of a more mature cell. These superinfected cells expressed both v-myb (at a level similar to that found before superinfection) and v-myc. It therefore appears that the expression of v-myc can elicit certain properties of a more differentiated phenotype. In addition, unlike cells transformed by v-myb alone, the cells expressing both v-myb and v-myc could not be induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate to differentiate to fully mature macrophages. Cells with a morphology similar to that of the superinfected cells were elicited by simultaneously infecting yolk sac macrophages with avian myeloblastosis virus and MC29. Such cells expressed both v-myb and v-myc. These results indicate that expression of v-myb and v-myc in infected cells coordinately regulates myelomonocytic phenotype and that the two viral oncogenes vary in their ability to interfere with tumor promoter-induced differentiation. Our findings also sustain previous suggestions that the oncogenes v-myb and v-myc may not transform target cells by simply blocking differentiation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-14582157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-215208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-222465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-227607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-2413449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-291929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-4131138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6087315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6096003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6098812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6195816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6198073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6205276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6253198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6260997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6267600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6278322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6283530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6297778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6304685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6305504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6308472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6308473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6309413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6310886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6313208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6316149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6327074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6699939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-6954533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3023905-7321107
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1796-802
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3023905-Animals,
pubmed-meshheading:3023905-Avian Sarcoma Viruses,
pubmed-meshheading:3023905-Avian leukosis virus,
pubmed-meshheading:3023905-Avian myeloblastosis virus,
pubmed-meshheading:3023905-Cell Differentiation,
pubmed-meshheading:3023905-Cell Line,
pubmed-meshheading:3023905-Cell Transformation, Neoplastic,
pubmed-meshheading:3023905-Chick Embryo,
pubmed-meshheading:3023905-Genes, Viral,
pubmed-meshheading:3023905-Oncogenes,
pubmed-meshheading:3023905-Phenotype,
pubmed-meshheading:3023905-Tetradecanoylphorbol Acetate
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pubmed:year |
1986
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pubmed:articleTitle |
Coordinate regulation of myelomonocytic phenotype by v-myb and v-myc.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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