3023895

Source:http://linkedlifedata.com/resource/pubmed/id/3023895

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003343, umls-concept:C0005595, umls-concept:C0008051, umls-concept:C0013935, umls-concept:C0016030, umls-concept:C0027651, umls-concept:C0032556, umls-concept:C0205263, umls-concept:C0206243, umls-concept:C0444598, umls-concept:C1510411, umls-concept:C1514926
pubmed:issue	5
pubmed:dateCreated	1987-1-20
pubmed:abstractText	The middle T antigen of polyomavirus transformed primary chicken embryo fibroblasts when expressed from a replication-competent avian retrovirus. This in vitro-constructed retrovirus, SRMT1, is a variant of Rous sarcoma virus that encodes the middle T antigen in place of v-src. Inoculation of SRMT1 into 1-week-old chickens rapidly induced hemangiomas and hemangiosarcomas. As shown with mammalian cells infected with polyomavirus, polyomavirus middle T antigen appears to be associated with p60c-src in chicken cells infected with SRMT1. When lysates of SRMT1-infected cells immunoprecipitated with either a monoclonal antibody against p60src or anti-T serum were assayed in an in vitro kinase reaction, the middle T antigen was heavily phosphorylated. To see whether an excess of p60c-src could alter the extent of phosphorylation of the middle T protein or the process of cell transformation by middle T, cells were doubly infected with SRMT1 and NY501, a virus which overexpresses p60c-src. Doubly infected chicken embryo fibroblasts transformed with the same kinetics and were morphologically indistinguishable from chicken embryo fibroblasts infected with SRMT1 alone. Phosphorylation of the middle T antigen was elevated two- to fivefold relative to cells infected only with SRMT1.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA14935, http://linkedlifedata.com/resource/pubmed/grant/CA18213, http://linkedlifedata.com/resource/pubmed/grant/RR01180
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-13557730, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-14115701, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-193255, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-203944, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-212612, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-213731, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-225866, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-229972, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-229973, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-229974, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-2411538, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-2426573, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-2426583, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-2582236, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-286319, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-2981357, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-2987799, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-2990725, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-2996218, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-2999420, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-4308272, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-4318787, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6087323, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6091900, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6184609, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6245258, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6251270, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6251451, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6251974, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6265803, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6284958, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6294529, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6304524, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6308472, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6308473, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6311433, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6312092, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6312293, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6325177, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6325896, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6325917, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-6330085, http://linkedlifedata.com/resource/pubmed/commentcorrection/3023895-73183
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8109087
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Polyomavirus Transforming, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral, Tumor, http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Viral, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0270-7306
pubmed:author	pubmed-author:CrossF RFR, pubmed-author:HanafusaHH, pubmed-author:HarbisonMM, pubmed-author:KornbluthSS
pubmed:issnType	Print
pubmed:volume	6
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1545-51
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:3023895-Animals, pubmed-meshheading:3023895-Antigens, Polyomavirus Transforming, pubmed-meshheading:3023895-Antigens, Viral, Tumor, pubmed-meshheading:3023895-Avian Sarcoma Viruses, pubmed-meshheading:3023895-Cell Transformation, Neoplastic, pubmed-meshheading:3023895-Chick Embryo, pubmed-meshheading:3023895-Chickens, pubmed-meshheading:3023895-Fibroblasts, pubmed-meshheading:3023895-Genetic Vectors, pubmed-meshheading:3023895-Oncogene Proteins, Viral, pubmed-meshheading:3023895-Plasmids, pubmed-meshheading:3023895-Polyomavirus, pubmed-meshheading:3023895-Protein Kinases, pubmed-meshheading:3023895-Rats, pubmed-meshheading:3023895-Sarcoma, Avian, pubmed-meshheading:3023895-Transfection
pubmed:year	1986
pubmed:articleTitle	Transformation of chicken embryo fibroblasts and tumor induction by the middle T antigen of polyomavirus carried in an avian retroviral vector.

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