Linked Life Data

3023751

Source:http://linkedlifedata.com/resource/pubmed/id/3023751

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-1-12
pubmed:abstractText
A cell line derived from the biopsy of a human hepatocellular carcinoma which retains the differentiated phenotype of the liver parenchymal cell is described. Comparison of the integration sites of hepatitis B virus within the cellular genome of the biopsy specimen and within the genome of the multiply-passaged cell line reveals five stable sites of viral integration in the host cell genome. Multiple chromosome abnormalities are found in this cell line, some in the same area of the genome in which abnormalities were found in other human hepatomas. Chromosomes obtained from the peripheral blood cultures of the same patient manifest multiple signs of chromosome instability including breaks, minutes, chromosome pulverization, and acentric fragments, some of which localize to the chromosomal sites involved in the abnormalities in the tumor cell line. Chromosomal instability and/or virus-induced chromosome damage as factors in the etiology of human hepatocellular carcinoma are discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0023-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
657-65
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Hepatocellular carcinoma cell line and peripheral blood lymphocytes from the same patient contain common chromosomal alterations.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.