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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1986-11-26
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pubmed:abstractText |
The effect of chronic lead treatment on pituitary dopamine (DA) D2 receptors was studied by measuring (-)sulpiride-displaceable [3H]spiroperidol-binding and DA-inhibited adenylate cyclase. Receptor number was reduced in lead-exposed animals and bromocriptine was less able to inhibit cyclase activity in pituitary homogenates. In addition, the capacity of DA to inhibit the VIP-stimulated cAMP formation was decreased.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0378-4274
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
255-60
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3022429-Adenylate Cyclase,
pubmed-meshheading:3022429-Animals,
pubmed-meshheading:3022429-Binding, Competitive,
pubmed-meshheading:3022429-Bromocriptine,
pubmed-meshheading:3022429-Cyclic AMP,
pubmed-meshheading:3022429-Dopamine,
pubmed-meshheading:3022429-Female,
pubmed-meshheading:3022429-Lead,
pubmed-meshheading:3022429-Pituitary Gland,
pubmed-meshheading:3022429-Rats,
pubmed-meshheading:3022429-Rats, Inbred Strains,
pubmed-meshheading:3022429-Receptors, Dopamine,
pubmed-meshheading:3022429-Spiperone,
pubmed-meshheading:3022429-Sulpiride
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pubmed:year |
1986
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pubmed:articleTitle |
Chronic lead exposure alters dopaminergic mechanisms in rat pituitary.
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pubmed:publicationType |
Journal Article
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