Linked Life Data

3022312

Source:http://linkedlifedata.com/resource/pubmed/id/3022312

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1986-12-10
pubmed:abstractText
Dose-response curves to leukotrienes B4 (LTB4), D4 (LTD4), PAF-acether and histamine applied as single or cumulative doses are studied on guinea-pig lung parenchymal strips (GPLP). A mole to mole comparison shows that PAF-acether is the most potent agonist, when GPLP contracts maximally to histamine. GPLP possesses specific receptors to histamine, LTD4 and PAF-acether which can be blocked by selective receptors antagonists: mepyramine as antihistaminic, FPL 55712 as anti-SRS-A substance, BN 52021 and kadsurenone as anti-PAF-receptor antagonists; meanwhile, a part of their action is mediated through the release of arachidonate metabolites. Histamine, LTB4, LTD4 and PAF-acether-induced contractions are all dependent on cyclooxygenase. Thromboxane A2 (TXA2) could be one of the cyclooxygenase products involved. A part of contractile effects of LTB4 and LTD4, but not of histamine, is liked to the generation of lipoxygenase metabolites as their contractions are partially inhibited by NDGA and ETYA. Contraction-induced by PAF-acether is reduced in presence of NDGA but not by FPL 55712, which indicates that lipoxygenase products other than peptidoleukotrienes are involved in the PAF-response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0031-6989
pubmed:author
pubmed:issnType
Print
pubmed:volume
18 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-110
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Comparative effects of drugs on leukotrienes-, PAF-acether- and histamine- induced contractions of guinea-pig lung parenchymal strips.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro