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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1986-12-5
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pubmed:abstractText |
Integrated hepatitis B virus (HBV) DNA is almost invariably found in hepatocellular carcinomas (HCC) which develop in HBV carriers. Integrated HBV DNAs from two single-integration HCCs (C3 and C4) have been cloned, and the cellular integration sites have been analyzed. Integrated HBV DNA of C3 is present in chromosome 6 and contains a nearly complete linear HBV genome. The HBV DNA integration in tumor C3 was not associated with major rearrangements of cellular DNA. In contrast, the integrated HBV DNA in C4 contains a large inverted repeat of HBV DNA, in which each repeat consists of a linear HBV DNA segment similar to that present in C3. The C4 integration was also accompanied by a cellular DNA translocation at the HBV integration site. The translocation occurred between chromosomes 17 and 18, along with a deletion of at least 1.3 kilobases of chromosome 18 DNA at the translocation site. Our data support a model in which postintegration rearrangement of integrated HBV and cellular DNA results in the generation of chromosomal aberrations. These chromosomal aberrations may function in a multistage mechanism leading to fully malignant HCC.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-2981782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-2982143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-2983098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-2989822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-2996131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-4571265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6087345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6088800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6092065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6118576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6258076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6268980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6288257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6294334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6298634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6299926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6302689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6306594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6309408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6322170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6328013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6499117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-656184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-6609441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-7188179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-7312030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-7438207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3022290-920780
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8338-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3022290-Base Sequence,
pubmed-meshheading:3022290-Carcinoma, Hepatocellular,
pubmed-meshheading:3022290-Chromosome Deletion,
pubmed-meshheading:3022290-Chromosome Mapping,
pubmed-meshheading:3022290-Chromosomes, Human, Pair 17,
pubmed-meshheading:3022290-Chromosomes, Human, Pair 18,
pubmed-meshheading:3022290-DNA, Viral,
pubmed-meshheading:3022290-Hepatitis B virus,
pubmed-meshheading:3022290-Humans,
pubmed-meshheading:3022290-Liver Neoplasms,
pubmed-meshheading:3022290-Nucleic Acid Hybridization,
pubmed-meshheading:3022290-Translocation, Genetic
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pubmed:year |
1986
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pubmed:articleTitle |
Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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