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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-12-3
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pubmed:abstractText |
Experimental induction of simian acquired immune deficiency syndrome (SAIDS) by inoculation of juvenile rhesus monkeys with a type D retrovirus was prevented by immunization with Formalin-killed whole SAIDS retrovirus serotype 1 containing the adjuvant threonyl muramyl-dipeptide. All six immunized animals developed neutralizing antibody after three injections, while six age-matched cagemates receiving adjuvant alone were antibody free. All 12 monkeys were challenged intravenously with a potentially lethal dose of SAIDS retrovirus serotype 1. The six immunized animals failed to develop persistent viremia and remained clinically normal 8 months postchallenge. In contrast, five of six nonvaccinates developed persistent viremia, four of six developed clinical SAIDS, and two of six died with SAIDS at 10 weeks and 8 months postchallenge, respectively. These results show that prevention of a common spontaneous retrovirus-induced immunosuppressive disease in macaques is now possible by vaccination.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-2410140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-2421920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-2981428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-2991655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-2995224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-2997923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-3000662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-3006247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-3006332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-3012358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-3159089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-3873705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-3963589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-6130381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-6200929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-6206563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-6221343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-6691418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-6695172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3021978-6695196
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
431-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3021978-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:3021978-Animals,
pubmed-meshheading:3021978-Antibodies, Viral,
pubmed-meshheading:3021978-Macaca mulatta,
pubmed-meshheading:3021978-Monkey Diseases,
pubmed-meshheading:3021978-Neutralization Tests,
pubmed-meshheading:3021978-Retroviridae,
pubmed-meshheading:3021978-Retroviridae Infections,
pubmed-meshheading:3021978-Vaccination,
pubmed-meshheading:3021978-Viral Vaccines
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pubmed:year |
1986
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pubmed:articleTitle |
Prevention of simian acquired immune deficiency syndrome with a formalin-inactivated type D retrovirus vaccine.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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