Linked Life Data

3021257

Source:http://linkedlifedata.com/resource/pubmed/id/3021257

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1986-12-11
pubmed:abstractText
Influence of synthetic water-soluble antioxidants gamma-(4-oxi-3,5-ditret-butylphenol) propionate (phenozan) and the potassium salt of phenozan on the signal processing in beta-receptor-adenylate-cyclase complex of rat cardiocyte membranes has been studied. It was demonstrated that these compounds act at the level of signal transduction from receptor to adenylate cyclase catalytic subunit rather than at the level of ligand-receptor complex formation. At concentrations exceeding-10 microM the antioxidants inhibit both isoproterenol-stimulated synthesis of cyclic 3',5'-AMP and accumulation of the products of lipid peroxidation in membranes. It is proposed that in vitro addition of antioxidants on cardiocyte beta-receptor-adenylate-cyclase complex is a result of alteration of physico-chemical properties of membrane lipids caused by these inhibitors of free radical reactions.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0365-9615
pubmed:author
pubmed:issnType
Print
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
415-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
[In vitro effect of synthetic water-soluble antioxidants of the class of screened phenols on the beta-adrenergic system in the cardiocyte plasma membranes of rats].
pubmed:publicationType
Journal Article, In Vitro, English Abstract