Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1986-10-30
pubmed:abstractText
Eighteen cases of Cushing's syndrome caused by ectopic production of peptide hormones were investigated by histological and immunocytochemical methods and the findings correlated with clinical and biochemical observations. Immunocytochemistry showed immunoreactive adrenocorticotrophic hormone (ACTH) or peptides derived from the ACTH precursor (pro-opiomelanocortin (POMC], or both, in a total of 10 cases: five of these also contained immunoreactive-alpha-melanocyte stimulating hormone, indicating more extensive translational processing of POMC than normally occurs in healthy corticotrophs of the anterior pituitary; in two further cases peptides capable of stimulating ACTH release from the anterior pituitary were present. In the remaining six cases immunocytochemistry failed to show the presence of ACTH, other POMC derived peptides, or peptides with ACTH releasing properties. These findings correlate well with the histological and clinical observations, in that the six tumours had been clinically overt, caused rapid death, and histologically seemed to be highly malignant. In contrast, the 12 other tumours were occult to radiological examination, patients had a much improved survival rate, and histologically the tumours seemed to be less aggressive. All but one of the tumours in this series showed a degree of neuroendocrine differentiation, indicated by the presence of neuron specific enolase. These results suggest that one feature of highly malignant tumours, which cause an ectopic endocrine syndrome, is a high secretion of peptide hormones, leaving amounts that are too small to be shown by immunocytochemistry.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-13693451, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-14471915, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-178136, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-2982899, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-2983908, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-3007321, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-3024870, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-4310919, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-4319342, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-4326719, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-4335588, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-4336515, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-4352098, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-4365972, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-5690727, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-6111674, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-6262069, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-6267699, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-6271390, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-6278938, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-6305538, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-6328303, http://linkedlifedata.com/resource/pubmed/commentcorrection/3020095-6574517
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9746
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
955-60
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:3020095-ACTH Syndrome, Ectopic, pubmed-meshheading:3020095-Adrenocorticotropic Hormone, pubmed-meshheading:3020095-Adult, pubmed-meshheading:3020095-Aged, pubmed-meshheading:3020095-Calcitonin, pubmed-meshheading:3020095-Colonic Neoplasms, pubmed-meshheading:3020095-Cushing Syndrome, pubmed-meshheading:3020095-Female, pubmed-meshheading:3020095-Gallbladder Neoplasms, pubmed-meshheading:3020095-Humans, pubmed-meshheading:3020095-Immune Sera, pubmed-meshheading:3020095-Immunoenzyme Techniques, pubmed-meshheading:3020095-Lung Neoplasms, pubmed-meshheading:3020095-Male, pubmed-meshheading:3020095-Melanocyte-Stimulating Hormones, pubmed-meshheading:3020095-Middle Aged, pubmed-meshheading:3020095-Neoplasms, pubmed-meshheading:3020095-Pancreatic Neoplasms, pubmed-meshheading:3020095-Paraneoplastic Endocrine Syndromes, pubmed-meshheading:3020095-Pro-Opiomelanocortin
pubmed:year
1986
pubmed:articleTitle
Immunocytochemical study of 18 tumours causing ectopic Cushing's syndrome.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't