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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1986-11-20
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pubmed:abstractText |
The functional significance of the reported affinity of (+)-3-PPP and (+)-N-allylnormetazocine (NANM) for the same binding site in rat brain membranes was assessed by studying (+)-3-PPP as a agonist and antagonist of (+)-NANM in rats trained to discriminate 5.0 mg/kg (+)-NANM from saline. Over a wide dose range, (+)-3-PPP was able to block the discriminative stimulus effects of (+)-NANM, with complete antagonism at 1.0 mg/kg i.p. Since (+)-NANM is a prototype sigma-opioid agonist, (+)-3-PPP is a good candidate for being a competitive sigma antagonist.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
127
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
283-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3019734-Animals,
pubmed-meshheading:3019734-Binding Sites,
pubmed-meshheading:3019734-Conditioning, Operant,
pubmed-meshheading:3019734-Discrimination (Psychology),
pubmed-meshheading:3019734-Generalization, Stimulus,
pubmed-meshheading:3019734-Phenazocine,
pubmed-meshheading:3019734-Piperidines,
pubmed-meshheading:3019734-Rats,
pubmed-meshheading:3019734-Rats, Inbred Strains,
pubmed-meshheading:3019734-Receptors, Opioid,
pubmed-meshheading:3019734-Receptors, Opioid, delta
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pubmed:year |
1986
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pubmed:articleTitle |
(+)-3-PPP antagonizes the discriminative stimulus effects of (+)-N-allylnormetazocine.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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