| pubmed-article:3019672 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3019672 | lifeskim:mentions | umls-concept:C0038975 | lld:lifeskim |
| pubmed-article:3019672 | lifeskim:mentions | umls-concept:C0041361 | lld:lifeskim |
| pubmed-article:3019672 | lifeskim:mentions | umls-concept:C1148735 | lld:lifeskim |
| pubmed-article:3019672 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:3019672 | pubmed:dateCreated | 1986-11-17 | lld:pubmed |
| pubmed-article:3019672 | pubmed:abstractText | Large tumor antigen (T antigen) was extracted from SV40-infected African Green Monkey cells and purified to homogeneity by immunoaffinity chromatography. The purified T antigen preparations unwind DNA duplices of greater than 120 bp in a reaction which is dependent on magnesium ions and ATP hydrolysis. Based on these and other properties of the reaction we classify this newly discovered enzymatic activity as a eukaryotic DNA helicase. The helicase and the known ATPase function of T antigen cosediment with the mono- or dimeric 4-6 S form of T antigen, but not with higher T antigen aggregates. The helicase activity seems to be an intrinsic function of SV40 T antigen. First, several different T antigen-specific monoclonal antibodies interfere with the DNA unwinding activity; monoclonals which are known to reduce the T antigen-specific ATPase most strongly inhibited the helicase reaction. Second, mutant T antigens with impaired ATPase function also showed a reduced DNA unwinding activity. | lld:pubmed |
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| pubmed-article:3019672 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3019672 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3019672 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3019672 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3019672 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3019672 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:3019672 | pubmed:author | pubmed-author:KnippersRR | lld:pubmed |
| pubmed-article:3019672 | pubmed:author | pubmed-author:StahlHH | lld:pubmed |
| pubmed-article:3019672 | pubmed:author | pubmed-author:DrögePP | lld:pubmed |
| pubmed-article:3019672 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3019672 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:3019672 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3019672 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3019672 | pubmed:pagination | 1939-44 | lld:pubmed |
| pubmed-article:3019672 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3019672 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3019672 | pubmed:articleTitle | DNA helicase activity of SV40 large tumor antigen. | lld:pubmed |
| pubmed-article:3019672 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3019672 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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