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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1986-10-23
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pubmed:abstractText |
The inhibition of pig liver fructose 1,6-bisphosphatase by fructose 2,6-bisphosphate has been investigated over a wide range of substrate concentration by measuring the release of labelled inorganic phosphate from [1-32P]fructose 1,6-bisphosphate. The activity of the enzyme can be inhibited completely by fructose 2,6-bisphosphate. The inhibiting effect is most pronounced at low substrate concentrations. The results have been analyzed in terms of a mathematical model assuming a competitive interaction of fructose 1,6-bisphosphate and fructose 2,6-bisphosphate at the catalytic site as well as a synergistic cooperation of the two hexose bisphosphates at an inhibiting allosteric site of the enzyme.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0232-766X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
45
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
713-7
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3019326-Animals,
pubmed-meshheading:3019326-Fructose-Bisphosphatase,
pubmed-meshheading:3019326-Fructosediphosphates,
pubmed-meshheading:3019326-Hexosediphosphates,
pubmed-meshheading:3019326-Kinetics,
pubmed-meshheading:3019326-Liver,
pubmed-meshheading:3019326-Models, Biological,
pubmed-meshheading:3019326-Swine
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pubmed:year |
1986
|
pubmed:articleTitle |
Inhibition of fructose 1,6-bisphosphatase from pig liver by fructose 2,6-bisphosphate.
|
pubmed:publicationType |
Journal Article,
In Vitro
|