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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1986-10-6
|
| pubmed:abstractText |
The efficacy of a novel consensus form of human alpha interferon designated IFN-alpha Con1 was evaluated against herpesvirus infections in vitro and in vivo. At comparable antiviral concentrations, natural lymphoblastoid IFN, IFN-alpha Con1, the molecular subtype IFN-alpha, and the hybrid IFN-alpha AD(Bgl) obtained by recombinant DNA methods conferred similar protection against herpes simplex virus type 1 and type 2 (HSV-2) infections of human cells in vitro. Whereas 7 X 10(5) U of IFN-alpha AD(Bgl) administered in 7 intraperitoneal (i.p.) doses between -4 and 96 h relative to infection protected 90% of mice from a lethal HSV-2 infection, a similar treatment regimen with IFN-alpha Con1 conferred no protection. Systemic HSV-2 infection of hamsters was rapidly lethal, but a single i.p. treatment with 10(6) U of either IFN-alpha Con1 or IFN-alpha AD(Bgl) was highly effective and protected 90 and 75% of animals, respectively, when given 6 h before infection; treatment with IFN-alpha Con1 protected 45% of animals when administered 10 h after infection. In addition, IFN-alpha Con1 was highly protective against acute cervicovaginal HSV-2 infection of hamsters when administered either in a single i.p. dose of 10(6) U at -6 or 10 h relative to infection or in multiple i.p. doses of 10(6) U between -6 and 120 h relative to infection. Protection was manifested by a delay in the onset of and a reduction in duration of infection, a reduction in the number of positive cervicovaginal infections, and an increase in the survival rate.
|
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3019238-208035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3019238-221812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3019238-6172550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3019238-6173327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3019238-6175298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3019238-6191986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3019238-6253403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3019238-6300256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3019238-6303322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3019238-6313295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3019238-6610387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3019238-6684674
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0066-4804
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
52-6
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:3019238-Animals,
pubmed-meshheading:3019238-Cells, Cultured,
pubmed-meshheading:3019238-Cricetinae,
pubmed-meshheading:3019238-Female,
pubmed-meshheading:3019238-Herpes Simplex,
pubmed-meshheading:3019238-Interferon Type I,
pubmed-meshheading:3019238-Male,
pubmed-meshheading:3019238-Mesocricetus,
pubmed-meshheading:3019238-Mice,
pubmed-meshheading:3019238-Mice, Inbred BALB C,
pubmed-meshheading:3019238-Recombinant Proteins,
pubmed-meshheading:3019238-Simplexvirus
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Antiherpetic effects of a human alpha interferon analog, IFN-alpha Con1, in hamsters.
|
| pubmed:publicationType |
Journal Article
|