Linked Life Data

3019182

Source:http://linkedlifedata.com/resource/pubmed/id/3019182

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-10-22
pubmed:abstractText
The influence of an anaphylactic challenge on the relaxing effects of isoproterenol, prostaglandin E1 (PGE1), forskolin, and aminophylline was examined using an isolated tracheal muscle preparation from ovalbumin (OA)-sensitized guinea pigs. As compared with histamine (4 X 10(-5) M) challenge, an anaphylactic challenge with OA (5 micrograms/mL) caused a rightward shift of the concentration-response curves for isoproterenol, PGE1, and forskolin but not for aminophylline. Their 50% effective concentrations were increased by about 1.7- to 2.8-fold of the histamine challenged preparations. These results indicate that anaphylactic challenge of the sensitized guinea pig tracheal muscle diminishes relaxing effects of isoproterenol, PGE1, and forskolin but not aminophylline. Possible mechanisms of these subsensitivities may involve both impaired coupling mechanism between receptor and adenylate cyclase and decreased adenylate cyclase activity, rather than their receptor numbers or affinity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-4738
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-24
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Experimental model of anaphylaxis-induced beta-adrenergic blockade in the airways.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't