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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1986-10-6
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pubmed:abstractText |
Binding of [3H]thyrotropin-releasing hormone (TRH) to its receptors in the rat limbic forebrain was partially displaced by 5-hydroxytryptamine (5-HT, ligand for 5-HT1 receptors) and (+)-lysergic acid diethylamide ((+)-LSD, ligand for 5-HT1 and 5-HT2 receptors) at nanomolar concentrations. Spiperone (ligand for 5-HT2 receptors) displaced [3H]TRH in a dose-dependent manner at micromolar concentrations. These results suggest that some TRH receptors are related to 5-HT1 receptors, probably adjoining them on the membrane. This type of TRH receptor is shown to be among the high-affinity receptors which we reported previously. The significance of the receptor-coexistence is such that TRH facilitates serotonergic transmission by increasing the density of 5-HT1 receptors. This finding seems to support a pharmacological observation of other investigators that TRH potentiates 5-HT-induced hyperactivity in mice, probably by affecting postsynaptic 5-HT receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0167-0115
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
293-9
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:3018845-Animals,
pubmed-meshheading:3018845-Binding, Competitive,
pubmed-meshheading:3018845-Brain,
pubmed-meshheading:3018845-Kinetics,
pubmed-meshheading:3018845-Limbic System,
pubmed-meshheading:3018845-Lysergic Acid Diethylamide,
pubmed-meshheading:3018845-Male,
pubmed-meshheading:3018845-Rats,
pubmed-meshheading:3018845-Rats, Inbred Strains,
pubmed-meshheading:3018845-Receptors, Cell Surface,
pubmed-meshheading:3018845-Receptors, Thyrotropin-Releasing Hormone,
pubmed-meshheading:3018845-Serotonin,
pubmed-meshheading:3018845-Thyrotropin-Releasing Hormone,
pubmed-meshheading:3018845-Tissue Distribution
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pubmed:year |
1986
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pubmed:articleTitle |
5-Hydroxytryptamine and (+)-lysergic acid diethylamide displace [3H]thyrotropin-releasing hormone at its binding sites in the rat limbic forebrain.
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pubmed:publicationType |
Journal Article
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