Linked Life Data

3018608

Source:http://linkedlifedata.com/resource/pubmed/id/3018608

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-10-6
pubmed:abstractText
The predominant psychoactive constituent of marijuana, delta 9-tetrahydrocannabinol (THC), blocks the preovulatory luteinizing hormone (LH) surge and ovulation in rats treated with THC (10 mg/kg body weight) during the early afternoon of proestrus. When THC-blocked proestrous rats were subjected to unilateral electrochemical stimulation (100 microA anodal DC for 45 s) in the medial preoptic area (mPOA), serum LH was significantly elevated at 30, 60 and 90 min after stimulation in comparison with LH levels measured in sham-stimulated control animals at those times. The induced LH release was sufficient to elicit ovulatory responses comparable to the spontaneous ovulations observed in control rats treated only with the drug vehicle. These results are consistent with the hypothesis that THC inhibits gonadotropin secretion by action within the central nervous system, but demonstrate that the central inhibitory effect of THC does not prevent the release of LH-releasing hormone (LHRH) when the LHRH neurosecretory units are activated by brain stimulation. Thus, the antiovulatory effect of THC appears to result from an inhibition of LH secretion which does not involve the direct blockade of LHRH release.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
471-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Induction of luteinizing hormone release by electrochemical stimulation of the medial preoptic area in delta 9-tetrahydrocannabinol-blocked proestrous rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.