| pubmed-article:3018514 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:3018514 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:3018514 | lifeskim:mentions | umls-concept:C0162867 | lld:lifeskim |
| pubmed-article:3018514 | lifeskim:mentions | umls-concept:C0028584 | lld:lifeskim |
| pubmed-article:3018514 | lifeskim:mentions | umls-concept:C0014239 | lld:lifeskim |
| pubmed-article:3018514 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:3018514 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:3018514 | lifeskim:mentions | umls-concept:C0041361 | lld:lifeskim |
| pubmed-article:3018514 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:3018514 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:3018514 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:3018514 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:3018514 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:3018514 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:3018514 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:3018514 | pubmed:dateCreated | 1986-9-29 | lld:pubmed |
| pubmed-article:3018514 | pubmed:abstractText | Rat embryo cell lines containing the adenovirus 2 E1a region together with normal or mutant forms of the N-terminal half of the E1b region (HindIII G fragment) were generated by using a dominant selection marker, neo. Biochemically transformed cells containing a nonmutated HindIII G fragment proliferated more rapidly in Ca2+-deficient media, whereas cells containing a specific deletion within the E1b-encoded, 175-amino-acid (175R) (19-kilodalton) T-antigen gene and nontransformed cells grew at a slower rate. Furthermore, transformed cells that did not express the 175R T antigen and untransformed cells could not replicate their DNA efficiently in low-Ca2+ medium. Our results suggest that Ca2+ ions may provide an important stimulus for cell proliferation in adenovirus-transformed cells through a mechanism that involves the functions of the 175R T antigen. | lld:pubmed |
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| pubmed-article:3018514 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3018514 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3018514 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3018514 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3018514 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:3018514 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:3018514 | pubmed:author | pubmed-author:SubramaniamUU | lld:pubmed |
| pubmed-article:3018514 | pubmed:author | pubmed-author:ChinnaduraiGG | lld:pubmed |
| pubmed-article:3018514 | pubmed:author | pubmed-author:KuppuswamyMM | lld:pubmed |
| pubmed-article:3018514 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3018514 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:3018514 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3018514 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3018514 | pubmed:pagination | 3297-300 | lld:pubmed |
| pubmed-article:3018514 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3018514 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3018514 | pubmed:articleTitle | An adenovirus 2-coded tumor antigen located on the endoplasmic reticulum and nuclear envelope is required for growth of transformed cells in Ca2+-deficient media. | lld:pubmed |
| pubmed-article:3018514 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3018514 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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