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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
1986-10-6
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|
pubmed:abstractText |
Rats and mice were treated with lorazepam (1.0 mg/kg) or its vehicle. Six h later seizure threshold to i.v. pentylenetetrazole was determined following treatment with the benzodiazepine-receptor inverse agonist FG 7142, the antagonist Ro 15-1788 or a second dose of lorazepam. Although lorazepam alone was anticonvulsant 6 h after its administration, animals pretreated with lorazepam were more sensitive to the proconvulsant action of FG 7142 and less sensitive to the effects of a second treatment with lorazepam.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-8993
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|
pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
379
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
364-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3017512-Animals,
pubmed-meshheading:3017512-Benzodiazepinones,
pubmed-meshheading:3017512-Carbolines,
pubmed-meshheading:3017512-Convulsants,
pubmed-meshheading:3017512-Drug Interactions,
pubmed-meshheading:3017512-Flumazenil,
pubmed-meshheading:3017512-Injections, Intraperitoneal,
pubmed-meshheading:3017512-Lorazepam,
pubmed-meshheading:3017512-Mice,
pubmed-meshheading:3017512-Rats,
pubmed-meshheading:3017512-Receptors, GABA-A,
pubmed-meshheading:3017512-Species Specificity,
pubmed-meshheading:3017512-Time Factors
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pubmed:year |
1986
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|
pubmed:articleTitle |
Mice and rats are sensitized to the proconvulsant action of a benzodiazepine-receptor inverse agonist (FG 7142) following a single dose of lorazepam.
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pubmed:publicationType |
Journal Article,
Comparative Study
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