Linked Life Data

3017459

Source:http://linkedlifedata.com/resource/pubmed/id/3017459

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7-8
pubmed:dateCreated
1986-10-22
pubmed:abstractText
Liver regeneration is a good system for studying cell proliferation in an in vivo, physiologically controlled situation. Various hepatotrophic factors, neuromediators, hormones and growth factors, presumably acting in synergy, seem necessary to induce the switch from quiescence to proliferation. As a consequence of this activation, a number of changes occurs in the hepatocyte: modifications of the plasma membrane proteins; metabolic changes such as variations in albumin and fibrinogen concentrations, and induction of the acute phase proteins; induction of several specific mRNAs; variations in cAMP concentrations, and consequently in the activity of protein kinases and several other enzymes; modifications in chromosomal proteins; induction of proteins involved in DNA replication. A model has been constructed which is more a basis for reflexion than a theoretical model. It takes into account the possible connections between the different molecular events cited above. It is hypothesized that DNA replication is at least partly uncoupled from mitosis, and that the initial events of the proliferative response may be triggered by nutritional elements.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9084
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
957-67
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:articleTitle
Molecular biology of liver regeneration.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't