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rdf:type |
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lifeskim:mentions |
umls-concept:C0004793,
umls-concept:C0021920,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0026900,
umls-concept:C0027651,
umls-concept:C0029016,
umls-concept:C0072473,
umls-concept:C0079941,
umls-concept:C0085224,
umls-concept:C0678226,
umls-concept:C1274040,
umls-concept:C1414637,
umls-concept:C1442161,
umls-concept:C1655226,
umls-concept:C1879547
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pubmed:issue |
13
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pubmed:dateCreated |
1986-9-17
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pubmed:databankReference |
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pubmed:abstractText |
Bacteriophage libraries of mouse DNA were screened for sequences homologous to the v-myb oncogene and two overlapping clones containing the v-myb related region were isolated. Restriction enzyme mapping, heteroduplex analysis and nucleotide sequence analysis revealed the presence of nine exons. Six of these exons are homologous to the v-myb region while the other three exons are derived from the 5' region which is deleted in the viral oncogene. The sequences downstream to the sixth v-myb exon are not included in the 17 kbp of DNA sequences analyzed in this study. Comparison of the structure of the normal c-myb clone with its rearranged couterpart present in plasmacytoid lymphosarcomas revealed that the rearrangements occur in this locus as a result of viral integration. Present studies demonstrate that such a viral insertion interrupts the c-myb coding region at a region identical to that observed in the generation of the v-myb gene of avian myeloblastosis virus and results in the synthesis of mRNAs that lack the same 5' coding region.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-13864532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-172289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-2942669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-2989692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-2998780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-3023843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-3753748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-3921261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6090941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6093260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6254063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6283631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6297766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6304685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6304726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6304883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6305504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6306471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6319012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6320011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6324165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6334806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6514007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6585957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6606489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3016644-6687762
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5309-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3016644-Amino Acid Sequence,
pubmed-meshheading:3016644-Animals,
pubmed-meshheading:3016644-Avian myeloblastosis virus,
pubmed-meshheading:3016644-Base Sequence,
pubmed-meshheading:3016644-Chromosome Mapping,
pubmed-meshheading:3016644-DNA, Neoplasm,
pubmed-meshheading:3016644-DNA Restriction Enzymes,
pubmed-meshheading:3016644-Defective Viruses,
pubmed-meshheading:3016644-Gene Expression Regulation,
pubmed-meshheading:3016644-Lymphoma, Non-Hodgkin,
pubmed-meshheading:3016644-Mice,
pubmed-meshheading:3016644-Moloney murine leukemia virus,
pubmed-meshheading:3016644-Proto-Oncogenes,
pubmed-meshheading:3016644-Recombination, Genetic
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pubmed:year |
1986
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pubmed:articleTitle |
Structural organization and nucleotide sequence of mouse c-myb oncogene: activation in ABPL tumors is due to viral integration in an intron which results in the deletion of the 5' coding sequences.
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pubmed:publicationType |
Journal Article
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