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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1986-9-25
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pubmed:abstractText |
Events in pathogenesis and immunity during primary varicella-zoster virus (VZV) infection were examined in 64 healthy subjects and 21 immunocompromised patients. Activation of the interferon system and activation of circulating T lymphocytes were early immune responses that occurred during the incubation period in some healthy subjects. Elevated levels of 2-5A synthetase in peripheral blood mononuclear cells and detection of serum alpha interferon (IFN-alpha) and gamma interferon (IFN-gamma) were present in the majority of healthy subjects who had acute primary VZV infection. Expression of HLA-DR antigen occurred on circulating T lymphocytes from subjects with acute VZV infection. The early production of VZV-specific IgG or IgM antibodies did not correlate with the severity of the clinical infection, but the detection of T lymphocyte proliferation to VZV antigen within three days after the appearance of the varicella exanthem was associated with milder illness. The mean VZV-specific lymphocyte transformation for subjects with less than 100 lesions/m2 was 7.5 +/- 10.43 SD compared with 1.4 +/- 1.85 SD for those with greater than 400 lesions/m2 (P less than .05). Only one (7.7%) of 13 immunocompromised patients had early VZV-specific lymphocyte transformation compared with 19 (42%) of 45 healthy subjects (P less than .05). The rapid host response to primary VZV infection was associated with rapid termination of viremia in healthy subjects; VZV was isolated from only 11% of peripheral blood mononuclear cell samples cultured within 48 hr after the appearance of the exanthem.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
154
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
422-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3016110-Adolescent,
pubmed-meshheading:3016110-Adult,
pubmed-meshheading:3016110-Antibodies, Viral,
pubmed-meshheading:3016110-Antibody Formation,
pubmed-meshheading:3016110-Antigens, Surface,
pubmed-meshheading:3016110-Chickenpox,
pubmed-meshheading:3016110-Child,
pubmed-meshheading:3016110-Child, Preschool,
pubmed-meshheading:3016110-Herpesvirus 3, Human,
pubmed-meshheading:3016110-Humans,
pubmed-meshheading:3016110-Immune Tolerance,
pubmed-meshheading:3016110-Immunity, Cellular,
pubmed-meshheading:3016110-Immunoglobulin G,
pubmed-meshheading:3016110-Immunoglobulin M,
pubmed-meshheading:3016110-Interferon Type I,
pubmed-meshheading:3016110-Lymphocyte Activation,
pubmed-meshheading:3016110-T-Lymphocytes
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pubmed:year |
1986
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pubmed:articleTitle |
Early immune response in healthy and immunocompromised subjects with primary varicella-zoster virus infection.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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