Linked Life Data

3015811

Source:http://linkedlifedata.com/resource/pubmed/id/3015811

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-9-17
pubmed:abstractText
Alpha-2-adrenoreceptor density on intact platelets was evaluated in 17 sportsmen, 8 of whom were endurance-trained athletes. Receptor density was determined as being equivalent to 3H-Yohimbine, specifically bound on intact platelets. Adrenaline-induced aggregation of platelets in vitro was additionally ascertained. Bmax (maximal binding) and KD (dissociation constant) were significantly lower in endurance-trained athletes (148 fmol per 10(9) platelets, KD = 0.92 nmol) than in the nine nonendurance-trained individuals (284 fmol, KD = 1.79 nmol, P less than 0.01), amounting to 89 receptors per cell (endurance-trained subjects) and 171 (nonendurance-trained subjects). No significant change of receptor density or affinity was observed subsequent to exhaustive exercise in the group of eight endurance-trained individuals. Bmax values and oxygen uptake capacity correlated negatively (r = -0.78, P less than 0.001) and Bmax values and induced platelet aggregation in vitro positively (r = 0.79, P less than 0.001). Data may indicate a reduced sensitivity of platelets in endurance-trained subjects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0172-4622
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
172-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Alpha-2-adrenoreceptor density on intact platelets and adrenaline-induced platelet aggregation in endurance- and nonendurance-trained subjects.
pubmed:publicationType
Journal Article, Comparative Study