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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1977-9-2
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pubmed:abstractText |
We used immunofluorescence to examine the developmental relationship of Ia and IgD on B cells. Pre-B cells in fetal liver did not express Ia. Only very few surface IgM-positive (sIgM+) B cells in fetal spleen were found to be Ia+ and were weakly stained for Ia. After birth there was a linear increase in the proportion of sIgM+ spleen cells which expressed Ia, reaching 95% by 9 days. Adult bone marrow also contains a sizeable proportion of sIgM+ Ia- cells. Unstimulated cells from fetal or newborn liver and spleen expressed Ia at the same rate in culture. Anti-Ia antisera suppressed the LPS-induced differentiation of IgM and IgG plasma cells in cultures of neonatal lymphocytes. Ia was also detected on IgM and IgG plasma cells in vitro suggesting that lipopolysaccharide (LPS)-stimulated B cells by may express Ia antigens, induced by LPS, or appearing as part of normal differentiation. IgD did not appear on sIgM+ cells until 3 days of age and then rose slowly to reach adult levels later than Ia antigens.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-1080547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-1081105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-1082551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-1083879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-1084527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-1085328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-4128439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-4215039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-4542609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-4547437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-47889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-55062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-58052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-811748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-811749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-814466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/301548-822777
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
146
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
297-301
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:301548-Aging,
pubmed-meshheading:301548-Animals,
pubmed-meshheading:301548-B-Lymphocytes,
pubmed-meshheading:301548-Bone Marrow,
pubmed-meshheading:301548-Bone Marrow Cells,
pubmed-meshheading:301548-Cell Division,
pubmed-meshheading:301548-Histocompatibility Antigens,
pubmed-meshheading:301548-Immunoglobulin D,
pubmed-meshheading:301548-Immunoglobulin M,
pubmed-meshheading:301548-Lipopolysaccharides,
pubmed-meshheading:301548-Liver,
pubmed-meshheading:301548-Mice,
pubmed-meshheading:301548-Mice, Inbred Strains,
pubmed-meshheading:301548-Plasma Cells,
pubmed-meshheading:301548-Receptors, Antigen, B-Cell,
pubmed-meshheading:301548-Spleen
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pubmed:year |
1977
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pubmed:articleTitle |
Ontogeny of Ia and IgD on IgM-bearing B lymphocytes in mice.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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