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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1986-9-25
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pubmed:abstractText |
Sera from 31 HBsAg-positive Chinese patients with inoperable hepatocellular carcinoma (HCC) were tested for hepatitis B virus DNA (HBV DNA) by means of dot hybridisation and Southern blot technique. HBV DNA probes were prepared from human plasma. Eighteen of the patients were HBeAb-positive, 12 were HBeAg-positive and one case had neither marker. Serial specimens were obtained from 16 cases over 5-42 weeks, while the patients were treated with recombinant leukocyte A interferon (rIFN-A) or adriamycin. Seven patients (2 HBeAg-positive, 5 HBeAb-positive) were positive for HBV DNA. In two patients HBV DNA and HBV DNA polymerase (DNAp) appeared in serum weeks after rIFN-A or adriamycin treatment was started. In two other cases, HBV DNA that was initially present disappeared during rIFN-A treatment. In a fifth patient HBV DNA persisting after adriamycin treatment diminished after change of treatment to rIFN-A. With one possible exception the HBV DNA detectable by Southern blot technique was composed chiefly of sequences 2.2-3.2 kb size indicating the presence of unintegrated DNA forms. DNAp activities were raised in the presence of HBV DNA in 4 patients. These findings show that HBV replication can be activated or suppressed in advanced HCC. Treatment with rIFN-A may have been effective in suppressing HBV DNA synthesis, but the number of cases studied was too small to arrive at a definite conclusion on this point.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-220264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-3972231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-4372397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-6086483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-6118576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-6156790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-6169615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-6203813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-6225836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-6231137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-6286137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-6301965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-6587366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-69727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-7061996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3015183-7108493
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-73
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
pubmed-meshheading:3015183-Aged,
pubmed-meshheading:3015183-Base Sequence,
pubmed-meshheading:3015183-Carcinoma, Hepatocellular,
pubmed-meshheading:3015183-DNA, Viral,
pubmed-meshheading:3015183-Doxorubicin,
pubmed-meshheading:3015183-Electrophoresis, Agar Gel,
pubmed-meshheading:3015183-Hepatitis B Surface Antigens,
pubmed-meshheading:3015183-Hepatitis B virus,
pubmed-meshheading:3015183-Humans,
pubmed-meshheading:3015183-Interferon Type I,
pubmed-meshheading:3015183-Liver Neoplasms,
pubmed-meshheading:3015183-Nucleic Acid Hybridization
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pubmed:year |
1986
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pubmed:articleTitle |
Serum hepatitis B viral DNA in HBsAg-positive hepatocellular carcinoma treated with interferon or adriamycin.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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