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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
1986-8-20
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pubmed:abstractText |
Binding of radioactive vasopressin--but not of oxytocin--was detected by autoradiography and by labeling of membranes obtained from the rat superior cervical ganglion. In both instances binding could be displaced by V1 (smooth muscle-type) but not by V2 (kidney-type) agonists, indicating that the ganglionic vasopressin receptors are similar to those present on hepatocytes and vascular smooth muscle. In accordance with the V1 character of the receptors, vasopressin activated the turnover of membrane inositol lipids, and this effect was abolished by a structural analogue known to act as a vasopressor antagonist. A possible physiological role of vasopressin was suggested by intracellular recordings obtained from ganglion cells in vitro. Vasopressin induced a reduction in the amplitude of the fast excitatory postsynaptic potential evoked by electrical stimulation of the preganglionic nerve. This reduction in ganglionic transmission was antagonized by the same synthetic structural analogue that blocked the effect of vasopressin on inositol lipids. This study provides evidence for the presence of functional vasopressin receptors in a rat sympathetic ganglion and thus suggests that vasopressin may play a role in peripheral autonomic function.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-115910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-228205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-2992691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-2992930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-2999654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-3873031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-3882778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-6122696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-6140688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-6148075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-6179162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-6183613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-6193270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-6263733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-6313427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-6329430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-6646518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-6717603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-6877666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-7139327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-7150264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-7172022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-7181141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014544-7252979
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5335-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3014544-Animals,
pubmed-meshheading:3014544-Arginine Vasopressin,
pubmed-meshheading:3014544-Binding Sites,
pubmed-meshheading:3014544-Evoked Potentials,
pubmed-meshheading:3014544-Ganglia, Autonomic,
pubmed-meshheading:3014544-Inositol Phosphates,
pubmed-meshheading:3014544-Male,
pubmed-meshheading:3014544-Oxytocin,
pubmed-meshheading:3014544-Rats,
pubmed-meshheading:3014544-Rats, Inbred Strains,
pubmed-meshheading:3014544-Receptors, Angiotensin,
pubmed-meshheading:3014544-Receptors, Cell Surface,
pubmed-meshheading:3014544-Receptors, Vasopressin
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pubmed:year |
1986
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pubmed:articleTitle |
Biochemical and electrophysiological evidence of functional vasopressin receptors in the rat superior cervical ganglion.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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