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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1986-8-1
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pubmed:abstractText |
We have studied the genomic organization of the c-myc locus (MYC) from 121 human primary breast carcinomas. Two types of alterations were observed: (i) the c-myc protooncogene appeared to be amplified 2- to 15-fold in 38 (32%) of the carcinoma DNAs and (ii) a non-germ-line c-myc-related fragment of variable size was detected in 5 primary breast carcinoma DNAs. With three exceptions, all the tumors containing a genetic alteration of the c-myc locus were invasive ductal carcinomas. A significant correlation (P less than 0.02) was observed between patients more than 50 years old and the presence of a genetically altered c-myc. Enhanced levels of c-myc RNA were observed in 10 of 14 breast carcinomas examined. The c-myc gene was genetically altered in 6 of these 10 tumors. The frequency with which the c-myc gene is altered and its correlation with age suggest that it may play a role in the development of breast carcinomas.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-2996003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-2997622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-345245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-3860844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-3896352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-4028021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-4200179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-4415728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-6272269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-6285209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-6300869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-6327071,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-6488314,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-6719137,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-6955596,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3014513-7367867
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4834-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3014513-Adenofibroma,
pubmed-meshheading:3014513-Age Factors,
pubmed-meshheading:3014513-Breast Neoplasms,
pubmed-meshheading:3014513-Carcinoma,
pubmed-meshheading:3014513-Carcinoma, Intraductal, Noninfiltrating,
pubmed-meshheading:3014513-DNA, Neoplasm,
pubmed-meshheading:3014513-Female,
pubmed-meshheading:3014513-Gene Amplification,
pubmed-meshheading:3014513-Gene Expression Regulation,
pubmed-meshheading:3014513-Humans,
pubmed-meshheading:3014513-Male,
pubmed-meshheading:3014513-Proto-Oncogene Proteins,
pubmed-meshheading:3014513-Proto-Oncogenes,
pubmed-meshheading:3014513-Receptors, Estrogen
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pubmed:year |
1986
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pubmed:articleTitle |
Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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