Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1986-8-8
pubmed:abstractText
RNA mapping experiments and chloramphenicol acetyltransferase assays were used to analyze polyadenylation in COS cells of transcripts from derivatives of pSV2-neo and pSV2-cat, in which the SV40 early poly(A) signal has been modified. Neither the sequence A-A-U-A-A-A nor the sequences located immediately downstream from it in the SV40 early gene appear to function by themselves as a poly(A) signal. When combined, however, these two elements form a poly(A) signal whose efficiency and specificity closely resemble those of the wild type signal. The addition of six nucleotides between the A-A-U-A-A-A sequence and the poly(A) site has no detectable effect on the efficiency or site of polyadenylation. Deletion of the 60 nucleotides immediately upstream from the hexanucleotide also has no detectable effect on polyadenylation. Therefore, A-A-U-A-A-A and sequences downstream from it appear to be sufficient for SV40 early polyadenylation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-2579321, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-2580642, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-2866847, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-2987822, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-2987956, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-3016512, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-3018490, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-3018506, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-3936040, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-4018033, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-4504350, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-4831907, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-518835, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-519756, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6095108, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6113054, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6146135, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6149460, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6154876, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6194440, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6208611, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6243777, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6246368, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6260373, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6272839, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6286831, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6295879, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6298741, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6318092, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6325940, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6646217, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6744418, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6771020, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-6960240, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-729004, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-822353, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014439-90157
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0305-1048
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4939-52
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Requirement of A-A-U-A-A-A and adjacent downstream sequences for SV40 early polyadenylation.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.