|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0007776,
umls-concept:C0022655,
umls-concept:C0034493,
umls-concept:C0040979,
umls-concept:C0332208,
umls-concept:C0871261,
umls-concept:C1280500,
umls-concept:C1516698,
umls-concept:C1704632,
umls-concept:C1705480,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:dateCreated |
1986-7-25
|
|
pubmed:abstractText |
Anuran membrane studies suggest that the calcium-binding protein calmodulin is necessary for arginine vasopressin (AVP) to exert a hydro-osmotic effect. We therefore examined the effect of trifluoperazine and N-(6-aminohexyl)-5-chloro-1-naphtholene sulphonamide (W-7), chemically dissimilar calmodulin inhibitors, on hydraulic conductivity (Lp) response to AVP in rabbit cortical collecting tubules perfused in vitro. Trifluoperazine but not W-7 increased basal Lp in rabbit cortical collecting tubules. When cortical collecting tubules were pre-treated with either trifluoperazine or W-7, the effect of AVP to increase Lp was significantly inhibited. To determine the site of this inhibition, Lp responses to exogenous cyclic adenosine 3',5'-phosphate (AMP) were studied. Both trifluoperazine and W-7 pretreatment significantly inhibited the effect of a cyclic AMP analogue to increase rabbit cortical collecting tubule Lp. These results suggest that calmodulin may be an important mediator of the hydro-osmotic response to AVP in the mammalian cortical collecting tube by acting at a site or sites distal to cyclic AMP formation.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-164029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-164919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-170936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-201632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-225798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-227248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-418180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-4296382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-4329040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-5923067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6112163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6120010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6138140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6145333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6164816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6255807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6258483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6259206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6263286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6268633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6281080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6284165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6286920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6300378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6303518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6410000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6542143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6805461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6897280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6945588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6951189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-6990273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-7085878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-7087674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-7144734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-7176334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-7275976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014127-839529
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3',5'-Cyclic-AMP Phosphodiesterases,
http://linkedlifedata.com/resource/pubmed/chemical/8-((4-chlorophenyl)thio)cyclic-3',5'...,
http://linkedlifedata.com/resource/pubmed/chemical/Arginine Vasopressin,
http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Thionucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Trifluoperazine,
http://linkedlifedata.com/resource/pubmed/chemical/W 7
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0022-3751
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
372
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
41-50
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3014127-3',5'-Cyclic-AMP Phosphodiesterases,
pubmed-meshheading:3014127-Animals,
pubmed-meshheading:3014127-Arginine Vasopressin,
pubmed-meshheading:3014127-Calmodulin,
pubmed-meshheading:3014127-Cyclic AMP,
pubmed-meshheading:3014127-Kidney Tubules,
pubmed-meshheading:3014127-Kidney Tubules, Collecting,
pubmed-meshheading:3014127-Osmolar Concentration,
pubmed-meshheading:3014127-Osmosis,
pubmed-meshheading:3014127-Rabbits,
pubmed-meshheading:3014127-Sulfonamides,
pubmed-meshheading:3014127-Thionucleotides,
pubmed-meshheading:3014127-Trifluoperazine
|
|
pubmed:year |
1986
|
|
pubmed:articleTitle |
Effect of trifluoperazine on rabbit cortical collecting tubular response to vasopressin.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
|
