Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-8-1
pubmed:abstractText
Our results indicate that there are two major breakpoint cluster regions in chromosome 18 DNA for t(14;18) translocations in follicular lymphomas. The absence of a pFL-1 homologous transcript in a cell line containing a pFL-2-detectable translocation suggests that there may be two different pathogenetic consequences of t(14;18) translocations. One possibility is that, despite the distances between them (greater than 20 kb), breakpoints in the two cluster regions in some way affect transcription of the same gene product, which has not yet been identified. Alternatively, two separate transcriptional units may be involved. The availability of DNA probes for each of the two t(14;18) breakpoint cluster regions will allow further studies regarding the biologic significance of these two genetically distinct classes of t(14;18) translocations.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-2865728, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-3079673, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-322279, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-3874430, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-3881165, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-3919454, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-3924412, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-3929382, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-582296, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-6093263, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-6101209, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-6323249, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-6607475, http://linkedlifedata.com/resource/pubmed/commentcorrection/3014037-7133054
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
164
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
315-20
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't