Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1986-7-31
|
| pubmed:abstractText |
The prenatal and/or postweaning effects of a hypertensinogenic high NaCl-containing diet (8.0% NaCl, w/w) on (1) the regional distribution of alpha 1-adrenoceptors and muscarinic cholinergic receptor sites in the heart and (2) the predisposition/resistance to hypertension (HT) were assessed in the inbred Dahl HT-sensitive (S/JR) and HT-resistant (R/JR) rat. The density of alpha 1-adrenoceptors was reduced in the left ventricle but not consistently affected in the ventricular septum, right ventricle, or atria of S/JR offspring with NaCl-induced HT. Both normotensive and hypertensive S/JR rats also displayed a significantly greater density of cholinergic receptor sites in the atria but few consistent alterations in other regions of the heart, compared to R/JR rats. Maternal diet had no effect on the predisposition/resistance to salt-induced HT and little effect on the regional development of alpha 1-adrenoceptors and cholinergic receptor sites. The results of this study suggest that the reduced density of ventricular alpha 1-adrenoceptors in the S/JR strain is a consequence of HT while the elevated density of cholinergic receptors in the atria may be related to the genetic predisposition/resistance to HT.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Quinuclidinyl Benzilate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Muscarinic,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0165-1838
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
137-52
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3013968-Animals,
pubmed-meshheading:3013968-Animals, Newborn,
pubmed-meshheading:3013968-Blood Pressure,
pubmed-meshheading:3013968-Body Weight,
pubmed-meshheading:3013968-Cell Membrane,
pubmed-meshheading:3013968-Female,
pubmed-meshheading:3013968-Heart,
pubmed-meshheading:3013968-Heart Atria,
pubmed-meshheading:3013968-Heart Septum,
pubmed-meshheading:3013968-Heart Ventricles,
pubmed-meshheading:3013968-Hypertension,
pubmed-meshheading:3013968-Male,
pubmed-meshheading:3013968-Myocardium,
pubmed-meshheading:3013968-Prazosin,
pubmed-meshheading:3013968-Pregnancy,
pubmed-meshheading:3013968-Prenatal Exposure Delayed Effects,
pubmed-meshheading:3013968-Quinuclidinyl Benzilate,
pubmed-meshheading:3013968-Rats,
pubmed-meshheading:3013968-Rats, Inbred Strains,
pubmed-meshheading:3013968-Receptors, Adrenergic, alpha,
pubmed-meshheading:3013968-Receptors, Muscarinic,
pubmed-meshheading:3013968-Sodium Chloride,
pubmed-meshheading:3013968-Tissue Distribution
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Pre- and neonatal exposure of the Dahl rat to NaCl: development and regional distribution of myocardial alpha 1-adrenergic and cholinergic receptor sites.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|