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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1986-7-25
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pubmed:abstractText |
Zoster is uncommon before the age of 50 years in immunologically normal individuals, but it occurs with increased frequency in people who are immunosuppressed. A retrospective review of 300 patients with acquired immunodeficiency syndrome associated with Kaposi's sarcoma, revealed that 8% had prior zoster, a rate that is sevenfold greater than historic controls of the same age. We prospectively examined forty-eight patients, with no known immunodeficiency or signs of AIDS or AIDS related complex (ARC), who presented with zoster localized to the thoracic region. Forty-one patients had known risk factors for AIDS and thirty-five had antibody to the AIDS-associated virus (AAV) at the time of presentation. One seropositive subject had no known risk factors. Absolute lymphocyte counts, lymphocyte OKT4/OKT8 ratios, and lymphocyte mitogen responses were all depressed in subjects with antibody to AAV when compared with seronegative individuals. Seven of thirty-three AAV antibody-positive subjects, who could be followed longitudinally, developed AIDS from 1 to 28 months (mean = 13) after zoster. One antibody-negative subject seroconverted to become AAV seropositive 16 months after zoster and developed Kaposi's sarcoma 1 month later. These eight subjects had persistently low lymphocyte OKT4/OKT8 ratios and elevated beta-2 microglobulin. In patients at risk for AIDS, the occurrence of zoster may be one sign that heralds the marked depression of cellular immunity associated with AIDS or ARC.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
pubmed:issn |
0190-9622
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1023-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3013955-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:3013955-Adolescent,
pubmed-meshheading:3013955-Adult,
pubmed-meshheading:3013955-Antibodies, Viral,
pubmed-meshheading:3013955-Deltaretrovirus,
pubmed-meshheading:3013955-Female,
pubmed-meshheading:3013955-Herpes Zoster,
pubmed-meshheading:3013955-Herpesvirus 3, Human,
pubmed-meshheading:3013955-Humans,
pubmed-meshheading:3013955-Male,
pubmed-meshheading:3013955-Middle Aged,
pubmed-meshheading:3013955-Prospective Studies,
pubmed-meshheading:3013955-Risk,
pubmed-meshheading:3013955-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:3013955-T-Lymphocytes, Regulatory,
pubmed-meshheading:3013955-beta 2-Microglobulin
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pubmed:year |
1986
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pubmed:articleTitle |
Herpes zoster: a possible early clinical sign for development of acquired immunodeficiency syndrome in high-risk individuals.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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