|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1986-7-18
|
|
pubmed:abstractText |
This investigation addressed the role of major histocompatibility complex-encoded class I molecules in the activation and proliferation of human lymphocytes. We studied the effect of antibodies specific for HLA-A and HLA-B locus gene products on mitogen-stimulated peripheral blood mononuclear cell (PBMC) subpopulations. Three individually derived, well-characterized anti-HLA class I monoclonal antibodies were demonstrated to inhibit the proliferation of human PBMC stimulated by either OKT3 or the calcium ionophore ionomycin. The antibody directed against HLA-A, -B, and -C locus gene products (W6/32) and the antibody directed against HLA-B locus gene products (4E) inhibited proliferation induced by either mitogen by 70-90%. The HLA-A locus-specific antibody (131), though inhibiting ionomycin-induced proliferation by 80-90%, was much less effective when OKT3 was the stimulus. The inhibition affected T4+ and T8+ cells and was not mediated by DR+ accessory cells. The inhibitory effect of these antibodies was associated with a decrease in the level of interleukin 2 activity present in culture supernatants, decreased interleukin 2 receptor expression, and decreased transferrin receptor expression and was not overcome by the addition of exogenous interleukin 2. Our results suggest that HLA class I molecules are directly involved in the early critical events of human lymphocyte activation and proliferation.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-2415655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-2580898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-2981917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-2981919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-2987968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-2989712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-3005396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-310861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-3155544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-3159820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-3875683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-3965573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-4179068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-47901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6095092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6196229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6200434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6227663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6231105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6232463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6260508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6304712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6318117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6319431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6413637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6595252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6815269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6973605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6975300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-6975347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-75242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-87477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3012568-92183
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Ionomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Isoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transferrin
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
83
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4446-50
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3012568-Antibodies, Monoclonal,
pubmed-meshheading:3012568-Antigen-Presenting Cells,
pubmed-meshheading:3012568-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:3012568-Antigens, Surface,
pubmed-meshheading:3012568-Ethers,
pubmed-meshheading:3012568-HLA Antigens,
pubmed-meshheading:3012568-Humans,
pubmed-meshheading:3012568-Interleukin-2,
pubmed-meshheading:3012568-Ionomycin,
pubmed-meshheading:3012568-Isoantibodies,
pubmed-meshheading:3012568-Lymphocyte Activation,
pubmed-meshheading:3012568-Receptors, Cell Surface,
pubmed-meshheading:3012568-Receptors, Immunologic,
pubmed-meshheading:3012568-Receptors, Interleukin-2,
pubmed-meshheading:3012568-Receptors, Transferrin,
pubmed-meshheading:3012568-T-Lymphocytes
|
|
pubmed:year |
1986
|
|
pubmed:articleTitle |
Functional role of HLA class I cell-surface molecules in human T-lymphocyte activation and proliferation.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
