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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1986-6-27
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pubmed:abstractText |
Blood mononuclear cells from newborns and from adults, immune or nonimmune to herpes simplex virus, were cultured with IL 2 and herpes simplex virus and the amount of gamma-interferon in the supernatant measured after 3 days. The newborn and nonimmune adult cells made equivalent trace amounts of gamma-interferon in cultures containing either herpes simplex virus or IL 2 alone and there was a 5- to 10-fold increase in cultures containing both. Experiments in which the Leu 11+ cells were either depleted or enriched suggest that this subset of natural killer cells is both necessary and sufficient for gamma-interferon production in the absence of immune T cells.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0031-3998
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
20
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
398-401
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3012450-Adult,
pubmed-meshheading:3012450-Humans,
pubmed-meshheading:3012450-Infant, Newborn,
pubmed-meshheading:3012450-Interferon-gamma,
pubmed-meshheading:3012450-Interleukin-2,
pubmed-meshheading:3012450-Killer Cells, Natural,
pubmed-meshheading:3012450-Monocytes,
pubmed-meshheading:3012450-Simplexvirus
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pubmed:year |
1986
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pubmed:articleTitle |
Herpes simplex virus-stimulated gamma-interferon production by newborn mononuclear cells.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|