Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-7-8
pubmed:abstractText
In the present investigation, we injected d(CH2)5Tyr(Me)AVP, a specific VI vasopressin antagonist, into the intrathecal space of the spinal cord to determine whether spinal vasopressin-containing neurons contribute to the hemodynamic effects produced by stimulation of the paraventricular nucleus (PVN). The intrathecal antagonist reduced the cardiovascular effects of PVN stimulation, but also reduced the effects produced by stimulating 2 other brain sites which do not contain vasopressin cell bodies. In addition, intrathecal administration of the vasopressin antagonist had a similar effect in Brattleboro rats which do not produce vasopressin. In conscious rats with indwelling intrathecal catheters, the vasopressin antagonist produced reversible hindlimb paralysis. These data suggest that d(CH2)5Tyr(Me)AVP has nonspecific actions within the spinal cord not related to the blockade of vasopressin receptors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-8
pubmed:dateRevised
2008-8-16
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
A V1 vasopressin receptor antagonist has nonspecific neurodepressant actions in the spinal cord.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.