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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1986-7-18
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pubmed:abstractText |
Recent studies of platelet-derived growth factor (PDGF) have revealed several structural and functional similarities between this growth factor or components linked to its mechanism of action and certain oncogene products: PDGF itself has a structural homology with the transforming protein of simian sarcoma virus, the PDGF receptor has a functional homology (tyrosine kinase activity) with a family of oncogene products, and PDGF induces the expression of the cellular counterparts of myc and fos. In addition, several tumour cell lines have been found to produce PDGF-like growth factors, which may cause autocrine stimulation of growth. We interpret these findings as indicating that regulatory components along the PDGF-dependent mitogenic pathway may have oncogenic properties if they are inappropriately expressed or activated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0269-3518
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-76
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:3011826-Cell Line,
pubmed-meshheading:3011826-Cell Transformation, Viral,
pubmed-meshheading:3011826-Enzyme Activation,
pubmed-meshheading:3011826-Humans,
pubmed-meshheading:3011826-Mitosis,
pubmed-meshheading:3011826-Neoplasms,
pubmed-meshheading:3011826-Oncogenes,
pubmed-meshheading:3011826-Osteosarcoma,
pubmed-meshheading:3011826-Phosphorylation,
pubmed-meshheading:3011826-Platelet-Derived Growth Factor,
pubmed-meshheading:3011826-Protein Biosynthesis,
pubmed-meshheading:3011826-Protein-Tyrosine Kinases,
pubmed-meshheading:3011826-Receptors, Cell Surface,
pubmed-meshheading:3011826-Receptors, Platelet-Derived Growth Factor
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pubmed:year |
1985
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pubmed:articleTitle |
Platelet-derived growth factor: mechanism of action and relation to oncogenes.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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