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pubmed:abstractText |
Three endogenous peptides were assayed for bioactivity at an Aplysia neuromuscular junction. Evoked contractions were enhanced by Phe-Met-Arg-Phe-NH2 (FMRFamide) and suppressed by arginine vasotocin; small cardioactive peptide B (SCPB) also enhanced contractions at low concentrations, but caused suppression at higher doses. In accordance with their putative roles as neuromodulators, immunocytochemistry revealed FMRFamide-like and SCPB-like fibers on the muscle surface.
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