|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1986-5-30
|
|
pubmed:abstractText |
Localisation and pharmacological properties of the VIP receptor in human lung sections are described. The receptor density determined by saturation analysis using 125I-VIP is approx. 100 fmol/mg protein, with a Kd of approx. 600 pM. Inhibition of 125I-VIP binding with VIP and related peptides gives a rank order of potency: VIP greater than peptide histidine methionine greater than secretin. Light microscope autoradiography reveals specific VIP binding sites, with a high density over the pulmonary artery smooth muscle and the alveolar walls and with a lower density over the bronchial epithelium.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
21
|
|
pubmed:volume |
199
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
198-202
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:3009219-Autoradiography,
pubmed-meshheading:3009219-Binding, Competitive,
pubmed-meshheading:3009219-Humans,
pubmed-meshheading:3009219-Iodine Radioisotopes,
pubmed-meshheading:3009219-Kinetics,
pubmed-meshheading:3009219-Lung,
pubmed-meshheading:3009219-Receptors, Cell Surface,
pubmed-meshheading:3009219-Receptors, Vasoactive Intestinal Peptide,
pubmed-meshheading:3009219-Vasoactive Intestinal Peptide
|
|
pubmed:year |
1986
|
|
pubmed:articleTitle |
Autoradiographic localisation of VIP receptors in human lung.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
