Linked Life Data

3008991

Source:http://linkedlifedata.com/resource/pubmed/id/3008991

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-5-23
pubmed:abstractText
An aldehyde dehydrogenase (ALDH) with properties identical to those of the NADP+-dependent, tumor-associated aldehyde dehydrogenase appearing during rat hepatocarcinogenesis has been identified in normal rat urinary bladder. Like the tumor-associated aldehyde dehydrogenase, bladder NADP+-ALDH is cytosolic and preferentially oxidizes benzaldehyde-like aromatic aldehydes. Bladder ALDH is also extremely sensitive to the aldehyde dehydrogenase inhibitor disulfiram. Additionally, the electrophoretic mobility of bladder ALDH is identical to that of the NADP+-dependent, tumor-associated aldehyde dehydrogenase. Finally, antibodies to the tumor-associated ALDH cross-react with bladder aldehyde dehydrogenase. Histochemically, bladder aldehyde dehydrogenase is localized to the very active epithelial lining and to the inner and outer smooth muscle layers. The observation that normal urinary bladder possesses an enzyme activity very similar to one expressed during hepatocarcinogenesis, but not in normal liver, is consistent with the hypothesis that derepression of a gene normally repressed in liver is responsible for expression of the tumor-associated aldehyde dehydrogenase phenotype.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2502-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Identification of hepatocarcinogenesis-associated aldehyde dehydrogenase in normal rat urinary bladder.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.