| pubmed-article:30087 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:30087 | lifeskim:mentions | umls-concept:C0027740 | lld:lifeskim |
| pubmed-article:30087 | lifeskim:mentions | umls-concept:C1704387 | lld:lifeskim |
| pubmed-article:30087 | lifeskim:mentions | umls-concept:C0085262 | lld:lifeskim |
| pubmed-article:30087 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:30087 | lifeskim:mentions | umls-concept:C0041491 | lld:lifeskim |
| pubmed-article:30087 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:30087 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:30087 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:30087 | pubmed:dateCreated | 1978-12-27 | lld:pubmed |
| pubmed-article:30087 | pubmed:abstractText | We have established a clonal cell line, PC-G2, from an experimentally induced rat pheochromocytoma. Administration of nerve growth factor to PC-G2 causes a 4- to 8-fold induction in the specific activity of tyrosine hydroxylase [tyrosine 3-monooxygenase; L-tyrosine,tetrahydropteridine:oxygen oxidoreductase(3-hydroxylating); EC 1.14.16.2]. The response is elicited in a dose-dependent fashion, at concentrations above 0.1 microgram/ml. Antiserum to nerve growth factor inhibited the induction of tyrosine hydroxylase. Dexamethasone enhances the nerve growth factor-mediated elevation of tyrosine hydroxylase. After 3--4 days of exposure to nerve growth factor the maximal induction of tyrosine hydroxylase is seen, although a significant increase can be observed after 24 hr. In contrast to the PC-12 cell line (derived from the same tumor), in which neurite outgrowth occurs in response to nerve growth factor, there is no morphological change or alteration in growth rate of PC-G2 cells after exposure to nerve growth factor. | lld:pubmed |
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| pubmed-article:30087 | pubmed:language | eng | lld:pubmed |
| pubmed-article:30087 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:30087 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:30087 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:30087 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:30087 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:30087 | pubmed:author | pubmed-author:HerschmanH... | lld:pubmed |
| pubmed-article:30087 | pubmed:author | pubmed-author:GoodmanRR | lld:pubmed |
| pubmed-article:30087 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:30087 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:30087 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:30087 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:30087 | pubmed:pagination | 4587-90 | lld:pubmed |
| pubmed-article:30087 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:30087 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:30087 | pubmed:articleTitle | Nerve growth factor-mediated induction of tyrosine hydroxylase in a clonal pheochromocytoma cell line. | lld:pubmed |
| pubmed-article:30087 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:30087 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:30087 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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