Linked Life Data

3008737

Source:http://linkedlifedata.com/resource/pubmed/id/3008737

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-5-9
pubmed:abstractText
Primaquine increases the NAD(P)H dependent oxygen consumption and hydroxyl radical generation by extracts of Trypanosoma cruzi, the causative agent of Chagas' disease. Spin-trapping studies show that hydroxyl radical yield is completely inhibited by catalase and slightly increased by SOD, indicating that radical generation is dependent on the pair primaquine-NAD(P)H and their interaction product, H2O2. Primaquine effects upon Trypanosoma cruzi extracts are compared with those obtained with nifurtimox, a compound effective in the treatment of Chagas' disease. The observed similarity suggests that hydroxyl radical may be involved in the antiprotozoan activity of primaquine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
135
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1029-34
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Primaquine can mediate hydroxyl radical generation by Trypanosoma cruzi extracts.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't