Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1986-5-5
|
pubmed:abstractText |
Small groups of adult volunteers, in sequence, were inoculated orally with inactivated purified bovine rotavirus of strain NCDV, with live NCDV purified or unpurified and with two different NCDV X human rotavirus reassortant viruses. One of five volunteers given 200 micrograms of ultravioletinactivated NCDV developed a virus-neutralizing (VN) and a binding antibody response detected by enzyme-linked immunosorbent assay (ELISA). Four of 10 volunteers given from 1 X 10(6) to 1 X 10(8) p.f.u. of live NCDV developed VN antibody, but nine of 10 responded when ELISA, HAI and radioimmuno-precipitation tests for serum antibody were also considered. Two different NCDV X human serotype 1 Wa strain virus reassortants, each containing Wa gene segment 9 and the serotype 1 neutralization phenotype, were administered orally in doses up to 10(6) p.f.u. The reassortants were relatively ineffective in eliciting a serum antibody response at the dosage level employed.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0264-410X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
4
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
25-31
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3008459-Administration, Oral,
pubmed-meshheading:3008459-Adult,
pubmed-meshheading:3008459-Animals,
pubmed-meshheading:3008459-Antibodies, Viral,
pubmed-meshheading:3008459-Cattle,
pubmed-meshheading:3008459-Diarrhea, Infantile,
pubmed-meshheading:3008459-Humans,
pubmed-meshheading:3008459-Infant, Newborn,
pubmed-meshheading:3008459-Recombination, Genetic,
pubmed-meshheading:3008459-Rotavirus,
pubmed-meshheading:3008459-Rotavirus Infections,
pubmed-meshheading:3008459-Viral Vaccines
|
pubmed:year |
1986
|
pubmed:articleTitle |
Response of adult human volunteers to oral administration of bovine and bovine/human reassortant rotaviruses.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|